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  • Title: Susceptibility to apoptosis is enhanced in immature cortical neurons.
    Author: McDonald JW, Behrens MI, Chung C, Bhattacharyya T, Choi DW.
    Journal: Brain Res; 1997 Jun 13; 759(2):228-32. PubMed ID: 9221941.
    Abstract:
    The susceptibility of cortical neurons to two forms of apoptotic death was compared with susceptibility to excitotoxic death during development in vitro (DIV 4-21). Murine cortical cultures were exposed for 48 h to the phosphatase inhibitor cyclosporine, the protein kinase inhibitor staurosporine or the excitotoxin N-methyl-D-aspartate (NMDA). Susceptibility to apoptosis induced by staurosporine or cyclosporine was maximal between DIV 4-10 and declined from DIV 10 through 18. The opposite pattern was observed with susceptibility to NMDA receptor-mediated excitotoxic necrosis, which was minimal at DIV 6 and progressively increased through DIV 21.
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