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  • Title: Quinolone-resistance mutations in the topoisomerase IV parC gene of Acinetobacter baumannii.
    Author: Vila J, Ruiz J, Goñi P, Jimenez de Anta T.
    Journal: J Antimicrob Chemother; 1997 Jun; 39(6):757-62. PubMed ID: 9222045.
    Abstract:
    Mutations in the parC gene, which encodes a subunit of topoisomerase IV, were determined in 21 epidemiologically unrelated clinical isolates of Acinetobacter baumannii. Our studies highlight the conserved sequences in the quinolone-resistance-determining region of the parC gene from A. baumannii and other bacteria. Nine of ten isolates with MICs of ciprofloxacin of > or = 32 mg/L showed a change of Ser80 to Leu and one showed a change of Glu84 to Lys. These results suggest that ParC from A. baumannii is a secondary target for quinolones and that mutations at residues Ser80 and Glu84, when combined with mutations at Ser83 of GyrA, may render A. baumannii highly resistant to quinolones.
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