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  • Title: Molecular characterization of attenuated Junin virus strains.
    Author: Albariño CG, Ghiringhelli PD, Posik DM, Lozano ME, Ambrosio AM, Sanchez A, Romanowski V.
    Journal: J Gen Virol; 1997 Jul; 78 ( Pt 7)():1605-10. PubMed ID: 9225036.
    Abstract:
    The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper we report the nucleotide sequences of S RNA of Candid #1 and its more virulent ancestors XJ#44 and XJ (prototype). Their relationship to Junin virus wild-type MC2 strain and other closely and distantly related arenaviruses was also examined. Comparisons of the nucleotide and amino acid sequences of N and GPC genes from Candid #1 and its progenitor strains revealed some changes that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype.
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