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  • Title: Drug interactions with the nonsedating antihistamines.
    Author: Ament PW, Paterson A.
    Journal: Am Fam Physician; 1997 Jul; 56(1):223-31. PubMed ID: 9225677.
    Abstract:
    The nonsedating antihistamines are frequently prescribed agents. Well-documented drug-drug interactions with two of these agents, terfenadine and astemizole, may result in serious adverse effects, including death, when they are prescribed along with macrolide antibiotics and/or the antifungal agents itraconazole or ketoconazole. Fexofenadine and loratadine appear to be the least likely nonsedating antihistamines to interact with other medications and to result in a life-threatening interaction. This article reviews the known drug-drug interactions involving nonsedating antihistamines and provides a basis from which the clinician can predict potential interactions.
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