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  • Title: Clozapine in the management of bipolar and schizoaffective manic episodes resistant to standard treatment.
    Author: Mahmood T, Devlin M, Silverstone T.
    Journal: Aust N Z J Psychiatry; 1997 Jun; 31(3):424-6. PubMed ID: 9226089.
    Abstract:
    OBJECTIVE: To test the efficacy of clozapine in treatment-resistant manic episodes. CLINICAL PICTURE: Three cases, two with bipolar disorder (manic) and one of schizoaffective disorder (manic), were treated with clozapine. TREATMENT: Clozapine was used after the failure of standard antipsychotics and mood stabilizers. OUTCOME: All three cases were successfully treated. CONCLUSION: A controlled trial of clozapine in treatment-resistant bipolar and schizoaffective manic episodes is indicated.
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