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  • Title: Inhibition of rabbit gastric glucosamine synthetase activity by Cu2+, Zn2+ and Se4+.
    Author: Fujita T, Sakuma S, Takahashi K, Bohtani Y, Nishida H, Fujimoto Y.
    Journal: Res Commun Mol Pathol Pharmacol; 1997 May; 96(2):203-8. PubMed ID: 9226754.
    Abstract:
    The effects of Fe2+, Cu2+, Zn2+ and Se4+ on the activity of glucosamine synthetase, the rate-limiting enzyme of mucus synthesis, in rabbit gastric corporal mucosa were examined. Cu2+, Zn2+ and Se4+ inhibited the glucosamine synthetase activity at concentrations ranging from 1 to 10 microM (Cu2+, 8-98% inhibition; Zn2+, 10-99% inhibition; Se4+, 32-89% inhibition). The inhibitory effects of these three ions were much stronger than that of UDP-N-acetylglúcosamine known as a representative inhibitor of the glucosamine synthetase activity (10 microM, 52% inhibition). Fe2+ had no significant effect on the glucosamine synthetase activity up to 100 microM. These results suggest that Cu2+, Zn2+ and Se4+ can be potent inhibitors of gastric glucosamine synthetase activity.
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