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  • Title: Fulminant primary manifestation of Crohn's colitis "Hot Crohn's disease".
    Author: Heise W, Kersten O, Kassner KM, Birkenmeyer G, Grosse G, Niedobitek F.
    Journal: Z Gastroenterol; 1997 Jun; 35(6):481-90. PubMed ID: 9231992.
    Abstract:
    Following the very short course of a disease with watery diarrhea, fever, nausea, meteorism and a severe feeling of general illness, a 22-year-old patient was diagnosed as having a toxic megacolon, and a subtotal colectomy was carried out. The postoperative progression was uncomplicated and the patient recovered quickly. The examination of the operation specimen revealed a serious ulcerous colitis with relative omission of the rectum and the distal sigmoid colon. After critical evaluation of the histological findings, it was judged to be a fulminant Crohn's colitis and, for the purposes of differential diagnosis, differentiated from ulcerative colitis and colitis indeterminate. The formal pathogenesis of the inflammatory-ulcerous processes is discussed, in particular with regard to the activation of the macrophages and the very short anamnesis in a clinically established primary manifestation of the disease.
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