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  • Title: Behavioural subsensitivity induced by long-term administration of a low dose of haloperidol to rats.
    Author: Frussa-Filho R, Abílio VC, Bergamo M, Palermo-Neto J.
    Journal: J Pharm Pharmacol; 1997 Apr; 49(4):412-5. PubMed ID: 9232539.
    Abstract:
    This study examines the effects on open-field and stereotyped behaviour of rats of abrupt withdrawal from repeated treatment with a low (0.03 mg kg-1) dose of haloperidol. Single administration of this low dose of haloperidol significantly increased open-field locomotion without modifying apomorphine (0.5 or 2.0 mg kg-1)-induced stereotyped behaviour. Forty-eight hours after abrupt withdrawal from 0.03 mg kg-1 haloperidol (twice daily for 15 days) a significant decrease in locomotion frequency was observed, but no change was observed in apomorphine-induced stereotypy. Our results suggest that dopamine autoreceptor supersensitivity might be evaluated in a behavioural situation of absence of postsynaptic dopamine receptor supersensitivity.
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