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  • Title: [L-MTP-PE--a potential antineoplastic agent].
    Author: Dzierzbicka K, Gozdowska M, Kołodziejczyk AM.
    Journal: Postepy Hig Med Dosw; 1997; 51(2):227-36. PubMed ID: 9235567.
    Abstract:
    Muramyl tripeptide phosphatidylethanolamine (MTP-PE), a synthetic lipophilic analogue of muramyl dipeptide, stimulates monocytes/macrophages to kill a variety of tumor cells in vitro and in vivo. Encapsulation of MTP-PE into multilamellar liposomes (L-MTP-PE) was specifically designed for in vivo targeting to macrophages by i.v. infusion and is the only form of the drug currently available for clinical trials (CGP 19835A Lipid). L-MTP-PE is presently undergoing clinical trials in patients with recurrent osteosarcoma and melanoma. L-MTP-PE combined with other anticancer agents may thus improve long-term cure rates of patients with this diseases.
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