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  • Title: [Soft tissue changes in adults with acquired growth hormone deficiency during substitution treatment. A double-blind, randomized, placebo-controlled study after a year of treatment].
    Author: Hansen TB, Vahl N, Jørgensen JO, Christiansen JS, Hagen C.
    Journal: Ugeskr Laeger; 1997 Jul 07; 159(28):4394-9. PubMed ID: 9235736.
    Abstract:
    The aim of the study was to assess the influence of growth hormone (GH) on body composition in 29 adult persons with acquired growth hormone deficiency (GHD). The study was a double-blind placebo-controlled study of one year's duration. The treatment consisted of daily subcutaneous injections of GH (2.0 IU/m2, Norditropin) or placebo. Before and after one year's treatment, the patients were hospitalized for measurement of Dual-Energy X-ray Absorptiometry (DXA) in order to assess body composition (Fat mass (FM) + Lean Body Mass (LBM). In addition, fasting serum Insulin-like Growth Factor (IGF-I) was collected. The study showed a 200% increase in serum IGF-I. Regarding LBM a 5.7% increase was seen, and this was primarily due to an increase in LBM of the extremities, whereas FM was reduced by 21.5% mainly located truncally. Our data demonstrate that favorable changes in body composition are maintained during long-term, controlled GH treatment, which loads support to the concept of GH substitution in GH-deficient adults.
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