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  • Title: Effects of prostaglandin E1 and indomethacin on the stimulation-evoked overflow of 3H-noradrenaline from guinea-pig taenia.
    Author: Ishii T, Sakato M, Shimo Y.
    Journal: Eur J Pharmacol; 1977 Oct 15; 45(4):381-4. PubMed ID: 923647.
    Abstract:
    Prostaglandin E1 (5.8 X 10(-8) M) markedly and reversibly reduced the stimulation-evoked overflow of total tritium, while it had no effects on basal outflow. Indomethacin (8.4 X 10(-6) M) increased the stimulation-evoked overflow of total tritium at low frequencies (2--5 HZ), while it had no effect at high frequencies of stimulation (more than 10 HZ). It was concluded that endogenous prostaglandin E1 also plays a regulatory role in adrenergic inhibitory neurotransmission by inhibiting the noradrenaline release from adrenergic nerve terminals of the guinea-pig taenia caecum.
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