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  • Title: [Effect of obsidan on the systemic hemodynamics of dogs in ontogeny].
    Author: Brin VB.
    Journal: Farmakol Toksikol; 1977; 40(5):551-6. PubMed ID: 923777.
    Abstract:
    Investigations on dogs of different age have brought evidence that intravenous administration of 2 mg/kg of obsidan (propranolol hydrochloride) causes in 18-22-day old puppies a fall of arterial pressure due to a reduced cardiac ejection with little changing total vascular peripheral resistance. The frequency of the rhythm and conduction in the heart are slowed down. In dogs aged 3-5 years the arterial pressure remains unchanged, since the diminution of the cardiac output is attended by a greater vascular resistance.
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