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  • Title: [Fibrinolysis in the blood of animals exposed to the chronic per os use of a heparin-urea complex].
    Author: Kudriashov BA, Liapina LA.
    Journal: Farmakol Toksikol; 1977; 40(5):559-63. PubMed ID: 923778.
    Abstract:
    When given per os a complex heparin-urea produces in the organism an intensive anticoagulant and fibrinolytic background which makes itself manifest in 1 hour time and continues to exist for as long as 16 hours after the last (10th) introduction. Upon abolishing the intake of the complex the study figures for the coagulation, anticoagulation and fibrinolytic activity return back to their physiological level. Introduction per os of the complex heparin-urea did not cause any changes in the tissues of the liver, heart, lungs, spleen and kidneys, while administration by the same route of an equivalent amount of urea caused mainly an increased non-fermentative fibrinolysis in the kidneys.
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