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  • Title: Radiopaque contrast media. XLIV - Preclinical studies with a new nonionic contrast agent.
    Author: Felder E, Pitrè D, Tirone P.
    Journal: Farmaco Sci; 1977 Nov; 32(11):835-44. PubMed ID: 923795.
    Abstract:
    L-5-alpha-hydroxypropionylamino-2,4,6-triiodoisophthalic acid di-(1,3-dihydroxy-2-propylamide), abbreviated Iopamidol, a new non-ionic water soluble contrast agent for angiography, myelography, ventriculography and for contrast reinforced computer-assisted axial tomography is described. Extensive preclinical testing showed favorable physico-chemical features of the new compound, low systemic toxicity, excellent cardiovascular and renal tolerability, very mild effects on the blood-brain barrier and on nervous tissue.
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