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  • Title: [Tumoral vascularization: physiopathology and therapeutic prospects].
    Author: Ortéga N, Sordello S, Plouët J.
    Journal: Bull Cancer; 1997 Apr; 84(4):391-5. PubMed ID: 9238163.
    Abstract:
    The Folkman's hypothesis postulates that tumor or metastase development is angiogenesis dependent. Since 1971, several lines of experimental data have supported this hypothesis in particular during the past months. A better understanding of the functional balance existing between positive and negative regulators of endothelial cell proliferation has paved the way to new therapeutic prospects.
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