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  • Title: [Tribulations of the p16/MTS1/CDKN2 tumor gene suppressor: a continuing saga].
    Author: Larsen CJ.
    Journal: Bull Cancer; 1997 Apr; 84(4):427-30. PubMed ID: 9238169.
    Abstract:
    Since its recent discovery on chromosome 9p21 band, the p16INK4a/MTS1/CDKN2 gene has been reported as one of the most frequently impaired tumor suppressor genes (ranking second after p53) in a variety of malignancies, including acute lymphoblastic leukemias. In fact, the situation is likely to be more complex than expected: the gene has a very unusual status in that sense that it encodes two structurally unrelated but functionally similar proteins, p16INK4a and p19ARF. In this minireview, the present status of the gene is examined.
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