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  • Title: Optimization of the synthesis of peptide combinatorial libraries using a one-pot method.
    Author: Herman LW, Tarr G, Kates SA.
    Journal: Mol Divers; 1997; 2(3):147-55. PubMed ID: 9238645.
    Abstract:
    Conditions for the synthesis of synthetic peptide combinatorial libraries (SPCLs) from mixtures of amino acids were explored. In a one-pot synthesis, the effect of the starting concentrations of amino acids on the resulting library composition was studied, and the optimum balance of amino acids was determined. Protein sequencing, MALDI-TOF, and amino acid analysis were used for the evaluation of the libraries, and their relative merits-are discussed. The effects of continuous-flow automated synthesis instrumentation in conjunction with polyethylene glycol-polystyrene (PEG-PS) graft supports and various cleavage cocktails on the successful synthesis of SPCLs were examined.
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