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  • Title: Effect of activated charcoal on rifampicin absorption in man.
    Author: Orisakwe OE, Dioka CE, Okpogba AN, Orish CN, Ofoefule SI.
    Journal: Tokai J Exp Clin Med; 1996 Feb; 21(1):51-4. PubMed ID: 9239805.
    Abstract:
    The effect of activated charcoal (AC) on rifampicin excretion was investigated in six healthy volunteers. On three occasions, at weekly intervals, each subject received a 600 mg rifampicin with 350 ml of water; b+c one and two weeks later, 600 mg of rifampicin plus 7.5 and 15 g AC, respectively, in 350 ml of water as a charcoal slurry. Urinary levels of rifampicin were measured form 1-36 hr after ingestion. Treatment with AC led to 1.2 per cent urinary recovery of rifampicin; decreased excretion rate; and a much lower plateau indicative of reduced absorption.
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