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  • Title: Colony stimulating factor-1 in human follicular fluid.
    Author: Witt BR, Pollard JW.
    Journal: Fertil Steril; 1997 Aug; 68(2):259-64. PubMed ID: 9240253.
    Abstract:
    OBJECTIVE: To evaluate colony stimulating factor-1 (CSF-1) concentrations in serum and follicular fluid (FF) at the time of oocyte retrieval and to test for presence of messenger RNA (mRNA) for CSF-1 and its receptor, c-fms, in FF cells. DESIGN: Collection of serum and FF at the time of oocyte retrieval. SETTING: A university IVF program. PATIENT(S): Forty-five women undergoing oocyte retrieval for IVF. INTERVENTION(S): Serum and FF were obtained from 24 women, and FF only was obtained from 21 women. MAIN OUTCOME MEASURE(S): Colony-stimulating factor-1 concentrations were determined by RIA, and the presence of mRNA for CSF-1 and c-fms was determined by reverse transcriptase-polymerase chain reaction. RESULT(S): Mean FF concentrations of CSF-1 were significantly higher than mean serum levels (10.0 +/- 1.3 and 3.6 +/- 0.3 (+/-SE) ng/mL, respectively). Colony-stimulating factor-1 and c-fms message were detected in FF cells, and alternatively spliced forms of CSF-1 message were present. CONCLUSION(S): The presence of CSF-1, a primary regulator of tissue macrophages, in FF, and the presence of mRNA for CSF-1 and its receptor c-fms in FF-derived cells, suggest a role for this growth factor in ovarian function.
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