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  • Title: Members of the family of IL-6-type cytokines activate Stat5a in various cell types.
    Author: Piekorz RP, Nemetz C, Hocke GM.
    Journal: Biochem Biophys Res Commun; 1997 Jul 18; 236(2):438-43. PubMed ID: 9240457.
    Abstract:
    Interleukin-6 (IL-6)-type cytokines activate transcription factors Stat1 and Stat3 (signal transducers and activators of transcription). Here we report that leukemia inhibitory factor (LIF) and IL-6 activate Stat5a in M1 myeloid leukemia cells in addition. In murine embryonal stem (ES) cells stably transfected with an expression vector for Stat5a treatment with LIF resulted in tyrosine phosphorylation and DNA-binding of this transcription factor. Transfection of an expression construct for Stat5a in human hepatoma cells caused a dose-dependent increase in LIF-triggered transcriptional activity. Our data demonstrate that Stat5a is activated by IL-6-type cytokines and can mediate transcriptional activity in addition to Stat1 and Stat3.
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