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  • Title: Cholesterol Binding to Simple Micelles in Aqueous Bile-Salt-Cholesterol Solutions.
    Author: Liu CL.
    Journal: J Colloid Interface Sci; 1997 Jun 15; 190(2):261-8. PubMed ID: 9241165.
    Abstract:
    The true thermodynamic activity (A T ) of cholesterol (Ch) in aqueous solutions containing taurocholate (TC)-Ch was determined by employing a direct assay of a 1 x 2-cm silicone polymer film with 0.025 cm thickness. Using the A T data, information on the nature of micellar species present in the TC-Ch system, and employing a binding-site model previously developed for tauroursodeoxycholate (TUDC)-Ch and taurochenodeoxycholate (TCDC)-Ch systems, it appeared that the Ch-binding affinity for simple bile-salt micelles corresponds precisely with the order of hydrophobicity, TUDC < TC < TCDC. Further, although simple TC micelles and simple TCDC micelles have similar binding capacities, the first Ch binding to a simple TC micelle may not significantly facilitate the second Ch binding, as occurs in simple TCDC micelles. For TUDC-Ch, TC-Ch, and TCDC-Ch systems, the concentration of bound simple micelles increased with increasing A T values, whereas the unbound simple micelle concentration decreased proportionally. These results provide insights into the possible influence of bile-salt species on Ch-binding to simple micelles in bile-salt-Ch solutions.
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