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  • Title: Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins.
    Author: Královocová E, Blumauerová M, Vanĕk Z.
    Journal: Folia Microbiol (Praha); 1977; 22(5):321-8. PubMed ID: 924274.
    Abstract:
    The production of epsilon-pyrromycinone glycosides in Streptomyces galilaeus increased 12-fold, with respect to the wild strain, as a result of a sequential procedure including both natural selection and treatment with mutagens (nitrous acid, UV light and gamma-irradiation). Nitrous acid exhibited the highest mutagenic effect, both in increasing the productivity and in inducing blocked mutants. A mutant strain blocked in the biosynthesis of glycosides and accumulating free epsilon-pyrromycinone as the principal metabolite was obtained.
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