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  • Title: [The mechanisms of the stimulating effect of tissue basophils on the reparative processes in inflammation].
    Author: Klimenko NA, Tatarko SV.
    Journal: Morfologiia; 1997; 111(2):69-72. PubMed ID: 9244553.
    Abstract:
    Mast cells stimulating effect on reparative processes in inflammation involves histamine, serotonin and heparin. This was shown on the model of E. coli-induced acute infectious peritonitis in rats using antagonists of major biologically active mast cells products (histamine, serotonin and heparin)-dimedrole, cimetidine, ciproheptadine and protamine sulfate. Fibroblast accumulation is associated with histamine, influencing predominantly H1- and H2-receptors as well as with serotonin. Fibroblast proliferative synthetic ability increases through histamine action on H1-receptors and serotonin and heparin influence. Accumulation of monocytes-macrophages and their proliferative synthetic ability stimulation is affected by histamine (through H1-receptors) and serotonin.
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