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  • Title: [Aplastic anemia. Alternative treatment by bone marrow transplantation].
    Author: Fonseca T, Raposo J, Gomez B, d'Oliveira JJ, de Lacerda JM.
    Journal: Acta Med Port; 1997 Jan; 10(1):99-102. PubMed ID: 9245186.
    Abstract:
    We report a case of a 25-year-old woman, with the diagnosis of severe aplastic anemia without a histocompatible sibling donor for bone marrow transplantation. The patient has been treated successfully with a combination of two immunosuppressive agents, cyclosporine and antilymphocyte globulin, after not responding to primary therapy with corticosteroids and growth factors. She showed a complete response to treatment, with transfusional independence, after a follow-up of 14 months. The pathophysiology of aplastic anemia, the mechanism of action and secondary effects of these treatments are discussed.
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