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  • Title: The effect of some peptides from the hibernating brain on Ca2+ current in cardiac cells and on the activity of septal neurons.
    Author: Kokoz YM, Zenchenko KI, Alekseev AE, Korystova AF, Lankina DA, Ziganshin RH, Mikhaleva II, Ivanov VT.
    Journal: FEBS Lett; 1997 Jul 07; 411(1):71-6. PubMed ID: 9247145.
    Abstract:
    The effects of the peptides TSKYR and DY isolated from the brain of hibernating ground squirrels on Ca2+ current were studied. TSKYR activated Ca2+ current in frog auricle fibers and in single cells from frog ventricle whereas DY blocked Ca2+ current in both preparations. In isolated rat and ground squirrel cardiocytes, TSKYR had no effect on Ca2+ current, and DY increased it. In brain slices of rat, DY blocked the activity of medial septal neurons. TSKYR increased activity of septal neurons at the initial phase, which was followed by decrease of neuronal activity.
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