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  • Title: Propylthiouracil-induced cutaneous vasculitis.
    Author: Yarman S, Sandalci O, Tanakol R, Azizlerli H, Oguz H, Alagöl F.
    Journal: Int J Clin Pharmacol Ther; 1997 Jul; 35(7):282-6. PubMed ID: 9247841.
    Abstract:
    Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults. Generalized maculopapular and papular purpuric eruptions are perhaps the most common thionamide-induced reactions. We report 3 patients who developed cutaneous vasculitis which is a rare and serious side-effect during antithyroid drug therapy. The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.
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