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  • Title: In vitro evaluation of antifungal properties of 8.O.4'-neolignans.
    Author: Zacchino S, Rodríguez G, Pezzenati G, Orellana G, Enriz R, Gonzalez Sierra M.
    Journal: J Nat Prod; 1997 Jul; 60(7):659-62. PubMed ID: 9249968.
    Abstract:
    Eighteen racemic 8.O.4'-neolignans with six different substitution patterns in rings A and B, in their ketone and in their erythro and threo alcoholic forms, were evaluated for antifungal activity by the agar dilution method. Only the alcohols exhibited a broad spectrum of activities against Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, Tricophyton rubrum, and Epidermophyton floccosum. (+/-)-erythro-3,4-(methylenedioxy) -7-hydroxy-1'-allyl-3',5'-dimethoxy-8.O.4'-neolignan (11) was the most active compound in the series, and E. floccosum was the most susceptible species.
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