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  • Title: Skeletal metastases from soft-tissue sarcomas. Incidence, patterns, and radiological features.
    Author: Yoshikawa H, Ueda T, Mori S, Araki N, Kuratsu S, Uchida A, Ochi T.
    Journal: J Bone Joint Surg Br; 1997 Jul; 79(4):548-52. PubMed ID: 9250736.
    Abstract:
    We reviewed 277 patients with soft-tissue sarcoma (STS) treated between 1975 and 1995 to study the incidence, distribution, time of appearance, and radiological findings of skeletal metastases. Of these, 28 (10.1%) had metastases within a mean period of 18.6 months after admission. The incidence of skeletal metastases differed among the histological subtypes of sarcoma; alveolar soft-part sarcoma, dedifferentiated liposarcoma, angiosarcoma, and rhabdomyosarcoma tended to show higher incidences. The regional bones close to the primary tumour were affected in 13 (46.4%) of the 28 patients, and the axial bones in 18 (64.3%). Radiologically, the metastatic bony lesions predominantly showed osteolytic changes, and there were pathological fractures in 21 of 44 lesions.
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