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  • Title: Prophylactic treatment of migraine with bisoprolol: a placebo-controlled study.
    Author: van de Ven LL, Franke CL, Koehler PJ.
    Journal: Cephalalgia; 1997 Aug; 17(5):596-9. PubMed ID: 9251876.
    Abstract:
    The objective of the present study was to assess the efficacy of bisoprolol in migraine prophylaxis. A double-blind placebo-controlled study was conducted in 226 patients with migraine with or without aura, a migraine history of at least 2 years at least 3 documented attacks during the 28 days run-in period. The duration of treatment was 12 weeks following an initial 28 days' run-in period. Patients reported the number of attacks and their severity in a diary. Treatment with bisoprolol 5 mg resulted in a significant reduction in the frequency of migraine attacks (39% vs 22%) compared to placebo treatment (p < 0.05). Treatment had no effect on the duration and severity of the attacks. Bisoprolol was well tolerated.
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