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  • Title: Repeated administration intensifies the reinforcing effect of fencamfamine in rats.
    Author: DeLucia R, Planeta CS, Aizenstein ML, Scavone C.
    Journal: Gen Pharmacol; 1997 Aug; 29(2):265-7. PubMed ID: 9251911.
    Abstract:
    1. In the present study, we evaluated the role of repeated administration on conditioning place preference (CPP) induced by fencamfamine (FCF) in male rats. 2. Repeated FCF (3.5 mg/kg) or saline once or daily for ten consecutive days enhanced sniffing duration and decreased locomotion and rearing duration. 3. At the 3.5 mg/kg dose, FCF produced a significant place-preference effect. 4. Repeated exposures to FCF intensified its reinforcing properties. 5. These results suggest that repeated FCF administration sensitizes its rewarding effects, as with other addictive substances.
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