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  • Title: A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.
    Author: DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M.
    Journal: Nature; 1997 Aug 07; 388(6642):548-54. PubMed ID: 9252186.
    Abstract:
    Nuclear transcription factors of the NF-kappaB/Rel family are inhibited by IkappaB proteins, which inactivate NF-kappaB by trapping it in the cell cytoplasm. Phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB. A cytokine-activated protein kinase complex, IKK (for IkappaB kinase), has now been purified that phosphorylates IkappaBs on the sites that trigger their degradation. A component of IKK was molecularly cloned and identified as a serine kinase. IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-kappaB activation.
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