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  • Title: daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
    Author: Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G.
    Journal: Science; 1997 Aug 15; 277(5328):942-6. PubMed ID: 9252323.
    Abstract:
    A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. Decreased DAF-2 signaling also causes an increase in life-span. Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.
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