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  • Title: The role of nitric oxide in hyperaemic response to flicker in the retina and optic nerve in cats.
    Author: Kondo M, Wang L, Bill A.
    Journal: Acta Ophthalmol Scand; 1997 Jun; 75(3):232-5. PubMed ID: 9253963.
    Abstract:
    PURPOSE: To elucidate the role of nitric oxide (NO) in the eye and the flicker-induced vascular response. METHODS: The blood flow in the retina and different parts of the optic nerve was compared in cats treated with the NO-synthase blocker, N(G)-nitro-L-arginine methyl ester and in control animals. In both groups, one of the eyes was dark-adapted, the other was subjected to 8 Hz flickering light. The regional blood flow was measured with the microsphere method. RESULTS: In control animals, flickering light increased blood flow in the retina and optic nerve head by 39% and 256%, respectively. Pretreatment with N(G)-nitro-L-arginine methyl ester prevented this increase in retinal blood flow and markedly reduced the blood flow in the optic nerve heads. CONCLUSION: NO release may mediate much of the vasodilating effect of flicker in cats, and play a role in maintaining normal vascular tone in the optic nerve head.
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