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  • Title: Sequence of the VP7 gene of an atypical human rotavirus: evidence for genetic and antigenic drift.
    Author: Palombo EA, Bugg HC, Masendycz PJ, Bishop RF.
    Journal: DNA Seq; 1997; 7(5):307-11. PubMed ID: 9255522.
    Abstract:
    The nucleotide sequence of the gene encoding the outer capsid glycoprotein, VP7, isolated from a reassortant human rotavirus, M3014, was determined. The deduced amino acid sequence exhibited significant identity to the VP7 from a standard strain belonging to serotype G4, although the antigenic regions of the M3014 VP7 resembled sequences from both serotype G4 and G9 viruses. However, reactivity with G4 or G9 serotype-specific monoclonal antibodies was not observed. We suggest that the M3014 VP7 was derived from sequential mutation of a G4-like progenitor gene resulting in a protein with novel antigenic properties.
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