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  • Title: The effects of substituents introduced into 9-aminoacridine on frameshift mutagenicity and DNA binding affinity.
    Author: Tomosaka H, Omata S, Hasegawa E, Anzai K.
    Journal: Biosci Biotechnol Biochem; 1997 Jul; 61(7):1121-5. PubMed ID: 9255975.
    Abstract:
    Some derivatives of 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding affinity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding affinity, while the introduction of chlorine increased them. Halogenated derivatives of 1 showed higher toxicity against Salmonella typhimurium TA1537.
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