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  • Title: Activation of mitogen-activated protein kinase by the nociceptin receptor expressed in Chinese hamster ovary cells.
    Author: Fukuda K, Shoda T, Morikawa H, Kato S, Mori K.
    Journal: FEBS Lett; 1997 Jul 28; 412(2):290-4. PubMed ID: 9256237.
    Abstract:
    Activation of the nociceptin receptor stably expressed in Chinese hamster ovary cells induced a transient mitogen-activated protein kinase (MAPK) activation, via pertussis toxin-sensitive G-proteins. The nociceptin receptor-mediated MAPK activation was partially blocked by down-regulation or inhibition of protein kinase C, and suppressed by pretreatment with a phosphatidylcholine-specific phospholipase C inhibitor, D609. Furthermore, a tyrosine protein kinase inhibitor, genistein, and phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002, affected the nociceptin-induced MAPK activity. The nociceptin-induced MAPK activation may lead to activation of phospholipase A2 and induce changes in gene expression.
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