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  • Title: The presence of a transcription activation function in the hormone-binding domain of androgen receptor is revealed by studies in yeast cells.
    Author: Moilanen A, Rouleau N, Ikonen T, Palvimo JJ, Jänne OA.
    Journal: FEBS Lett; 1997 Jul 28; 412(2):355-8. PubMed ID: 9256251.
    Abstract:
    To assess the importance of various regions of the androgen receptor (AR) in transcriptional regulation, we have compared its activation functions (AFs) in yeast and mammalian cells. The receptor's amino-terminal region contains a major transcriptional activator (AF-1) in both cell types, whereas AF-2 in the ligand-binding domain (LBD) is very weak in mammalian cells but clearly functional in the yeast. Hormone-binding ability of LBD is mandatory for AF-2 to operate, as illustrated by mutated LBD constructs. The activity of AF-2 in yeast is severely attenuated when the hinge region is attached to LBD, suggesting that the former region modulates AF-2 in vivo, probably by presenting an interface for interacting proteins.
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