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  • Title: [NO inhalation therapy for post-operative pulmonary hypertensive crisis of the case of truncus arteriosus].
    Author: Gomi S, Atsumi N, Terada Y, Jikuya T, Mitsui T, Ninomiya H.
    Journal: Nihon Kyobu Geka Gakkai Zasshi; 1997 Jul; 45(7):1061-5. PubMed ID: 9256651.
    Abstract:
    Two-months-old baby underwent complete correction by Barbero-Marcial's procedure for type I truncus arteriosus. Postoperative hemo-dynamics was fairly stable immediately after the operation. However, the acute rise in pulmonary pressure occurred on the 2nd postoperative day. The pulmonary vasodilation therapy with prostaglandin E1 and amrinone had failed. Thirty ppm of inhaled nitric oxide (NO) was started and it resulted in an immediate decrease in pulmonary arterial pressure. Complete weaning from NO was achieved 9 days after surgery by simultaneous administration of PGE1 and amrinone. Although inhalation of NO reduced pulmonary arterial pressure, combination of PGE1 and amrinone with NO inhalation exerted a pulmonary vasodilation and brought the patient to full recovery in this case with pulmonary hypertensive crisis.
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