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  • Title: Expression of transforming growth factor beta in radiation interstitial pneumonitis.
    Author: Bai YH, Wang DW, Cui XM, Long JY, Cui CB, Jia CY, Song LW.
    Journal: J Environ Pathol Toxicol Oncol; 1997; 16(1):15-20. PubMed ID: 9256927.
    Abstract:
    We investigated the changes in transforming growth factor beta 1 (TGF-beta 1) mRNA and TGF-beta 3 protein expression that occur in radiation interstitial pneumonitis. We used TGF-beta 1-cDNA probe in situ hybridization and TGF-beta 3 polyclonal antibody in immunohistochemical techniques. Our results showed that the distribution of TGF-beta 1 mRNA and TGF-beta 3 protein basically coincided in blood vessels, airways, lung parenchyma, and alveolar macrophages. However, bronchial epithelial cells expressed only TGF-beta 3 proteins and no TGF-beta 1 mRNA. We found an increased expression of TGF-beta 1 mRNA and TGF-beta 3 proteins in radiation interstitial pneumonitis.
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