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  • Title: Relevance of Na,K-ATPase to local extracellular potassium homeostasis and modulation of synaptic transmission.
    Author: Gloor SM.
    Journal: FEBS Lett; 1997 Jul 21; 412(1):1-4. PubMed ID: 9257678.
    Abstract:
    The ion gradients generated by the Na,K-ATPase are essential for Na+-coupled transport systems, osmoregulation and restoration of ion concentrations in excitable tissues. Indirectly, the sodium pump controls intracellular Ca2+ concentration through the Na/Ca exchanger. In the nervous system various neurotransmitters can modulate Na,K-ATPase activity. The great diversity of Na,K-ATPase subunit isoforms, their complex spatial and temporal regulation of expression and their cellular localisation imply a functional role of the sodium pump in different regulatory pathways. Among these, potassium homeostasis and modulation of synaptic transmission are discussed here.
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