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  • Title: Intraventricular chemotherapy in neonatal meningitis.
    Author: Lee EL, Robinson MJ, Thong ML, Puthucheary SD, Ong TH, Ng KK.
    Journal: J Pediatr; 1977 Dec; 91(6):991-5. PubMed ID: 925837.
    Abstract:
    All of 16 infants with neonatal meningitis treated during a 30-month period were found to have accompanying ventriculitis at the time of the initial ventricular puncture. Fifteen of these infants were caused by gramm-negative organisms. All infants received antibiotics systemically and intraventricularly via an implanted ventriculostomy reservoir or by direct ventricular injection. Antibiotic concentrations within the ventricular fluid were monitored during chemotherapy; the complications encountered during treatment are discussed. Fifteen infants survived the infection; of these, seven infants were normal at follow-up examinations. In our experience intraventricular chemotherapy as an adjunct to systemic administration of antibiotics has greatly reduced the mortality rate in neonatal meningitis.
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