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  • Title: The first recurring chromosome translocation in hepatoblastoma: der(4)t(1;4)(q12;q34).
    Author: Schneider NR, Cooley LD, Finegold MJ, Douglass EC, Tomlinson GE.
    Journal: Genes Chromosomes Cancer; 1997 Aug; 19(4):291-4. PubMed ID: 9258666.
    Abstract:
    We report four cases of hepatoblastoma with a derivative chromosome 4 from an unbalanced translocation between the long arms of chromosomes 1 and 4, an aberration reported only rarely in isolated cases of other types of neoplasms. The abnormality in three hepatoblastomas was der(4)t(1;4)(q12;q34), whereas the fourth case appeared to have a der(4)t(q25;q32). All had hyperdiploid tumor karyotypes; however, in the case with t(q25;q32), the der(4) was the only abnormality in the stemline. We speculate that the oncogenetic event in our cases may be the loss of a gene on distal 4q or their alteration by juxtaposition to 1q12 heterochromatin.
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