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  • Title: Precautionary note for use of bisulfite in pharmaceutical formulations.
    Author: Munson JW, Hussain A, Bilous R.
    Journal: J Pharm Sci; 1977 Dec; 66(12):1775-6. PubMed ID: 925948.
    Abstract:
    The effect of sodium bisulfite on aspirin hydrolysis was studied at 40 degrees in the pH range of 6.5-7.5. Significant catalytic activity by the sulfite ion was observed. Second-order rate constants were calculated for this catalysis and compared to other buffer species. The sulfite ion was a much more efficient catalyst than acetate, phosphate, or carbonate.
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