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  • Title: Childhood-onset anorexia nervosa: towards identifying a biological substrate.
    Author: Gordon I, Lask B, Bryant-Waugh R, Christie D, Timimi S.
    Journal: Int J Eat Disord; 1997 Sep; 22(2):159-65. PubMed ID: 9261654.
    Abstract:
    OBJECTIVE: The etiology of anorexia nervosa is not fully understood, but is probably multifactorial, including a biological substrate. The purpose of this paper is to investigate the possible underlying biological substrate. METHOD: Fifteen children and adolescents aged 8-16 years underwent regional cerebral blood blow radioisotope scans. All fulfilled DSM-IV criteria for anorexia nervosa. Three of the girls had a follow-up scan when they had regained their lost weight. RESULTS: Thirteen of the 15 patients had unilateral temporal lobe hypoperfusion, 8 on the left side and 5 on the right. The abnormality persisted in the 3 girls who had a follow-up scan after weight restoration. DISCUSSION: This is the first report of reduced regional cerebral blood flow in childhood-onset anorexia nervosa, and suggests an underlying primary functional abnormality.
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