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  • Title: Nucleus accumbens lesions impair context, but not cue, conditioning in rats.
    Author: Riedel G, Harrington NR, Hall G, Macphail EM.
    Journal: Neuroreport; 1997 Jul 28; 8(11):2477-81. PubMed ID: 9261812.
    Abstract:
    Previous work has provided evidence of a role for the hippocampal formation in contextual as opposed to cue conditioning. Similar deficits have been observed after transection of the fimbria/fornix, part of which consists of the hippocampal-nucleus accumbens (N.Acc) connection arising from both the dorsal and ventral subiculum. By means of electrolytic lesions of the N.Acc, we showed that the subiculo-accumbens projection appears to participate in aversive conditioning to context, but not to a cue (tone). Freezing, measured as an index of learning, in the experimental context was greatly reduced in animals with lesions of the N.Acc, as compared with sham-operated controls. No difference was found in freezing to a distinct tone. These data lend further support to the notion that the N.Acc is an important interface between limbic structures and motor output.
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