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  • Title: In utero management of hydrops fetalis caused by critical aortic stenosis.
    Author: Bitar FF, Byrum CJ, Kveselis DA, Lawrence DA, Smith FC.
    Journal: Am J Perinatol; 1997 Aug; 14(7):389-91. PubMed ID: 9263557.
    Abstract:
    Hydrops fetalis is rarely associated with congestive heart failure caused by obstructive left-sided heart lesions. There are rare cases of live born neonates with critical congenital valvar aortic stenosis and hydrops reported in the literature, all with fatal outcomes. This report describes, to the best of our knowledge, the first two newborns who were diagnosed prenatally to have hydrops fetalis caused by critical valvar aortic stenosis, who were treated prenatally with digoxin and who postnatally had successful percutaneous balloon aortic valvuloplasty. Both patients had not only left but right ventricular dysfunction. We speculate that right ventricular dysfunction was a contributing factor in the development of hydrops in these patients and in utero medical therapy with digoxin is associated with resolution of the hydrops before delivery.
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