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  • Title: Regulation of parathyroid cell proliferation.
    Author: Silver J, Sela SB, Naveh-Many T.
    Journal: Curr Opin Nephrol Hypertens; 1997 Jul; 6(4):321-6. PubMed ID: 9263680.
    Abstract:
    The parathyroid normally has very few cells in mitosis but it retains the potential to proliferate. In-vivo studies in rats have demonstrated that hypocalcaemia and high serum phosphate both lead to an increase in the number of proliferating cells, which is relevant to the increased parathyroid cell proliferation in chronic renal failure. Hypophosphataemia and 1,25(OH)2D3 decrease parathyroid cell proliferation. Genetic factors have been defined for multiple endocrine neoplasia which includes parathyroid cell hyperplasia, and in some parathyroid adenomas there are genetic rearrangements.
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