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  • Title: Neuronal ceroid-lipofuscinosis in a domestic cat: clinical, morphological and immunohistochemical findings.
    Author: Weissenböck H, Rössel C.
    Journal: J Comp Pathol; 1997 Jul; 117(1):17-24. PubMed ID: 9263841.
    Abstract:
    A 9-month-old domestic shorthair cat was humanely killed because of uncoordinated gait, myoclonus, seizures and reduced vision. Histological, immunohistochemical and ultrastructural examination revealed a neuronal storage disease consistent with neuronal ceroid-lipofuscinosis (NCL). Neurons contained Sudan black- and luxol fast blue-positive material which was autofluorescent. Immunohistochemically, the storage material was found to contain subunit c of mitochondrial ATP synthase, a protein recently recognized as the main component of the storage material in NCL. Ultrastructurally, the material consisted of curvilinear and fingerprint bodies, which are indicative of NCL.
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