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  • Title: Structure-activity relationship studies of CNS agents, Part 32: Effect of structural modifications in 1-arylpiperazine derivatives on alpha(1) -adrenoreceptor affinity.
    Author: Mokrosz MJ, Paluchowska MH, Charakchieva-Minol S, Bień A.
    Journal: Arch Pharm (Weinheim); 1997 Jun; 330(6):177-80. PubMed ID: 9264242.
    Abstract:
    The alpha(1)-adrenergic and 5-HT1A serotonergic receptor affinities of a series of 1-arylpiperazines are presented. The role of the spacer and the influence of the terminal substituents on the alpha(1)-adrenoreceptor affinity and the 5-HT1A/alpha(1) receptor selectivity are discussed.
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