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  • Title: Thymic microvascular system.
    Author: Kato S.
    Journal: Microsc Res Tech; 1997 Aug 01; 38(3):287-99. PubMed ID: 9264340.
    Abstract:
    Morphological studies of the microcirculatory system in the thymus were reviewed in regards to methodology and structural organization of blood and lymphatic vessels. The blood capillaries and postcapillary venules (PCVs) in the thymus are characterized by a double-walled structure. These vessels are surrounded more or less by perivascular spaces (PVSs) containing many lymphocytes. This space is delimited on the one side by abluminal surface of the vascular endothelium and on the other side by cytoplasmic processes of epithelial reticular cells. There are interruptions or gaps on the outer epithelial reticular layer. The lymphatic vessels can be distinguished histochemically from blood vessels based on strong 5'-nucleotidase (5'-Nase) activity. The 5'-Nase-positive lymphatic vessels were seen predominantly in the capsule and interlobular connective tissue but sometimes in the immediate vicinity of the PVS around the PCV, when a discrete opening in the lymphatic wall next to the PVS was found. Thus, it may be regarded as an initial part of lymphatics closely associated with the PVS, suggesting a possible route for lymphocyte efflux into the lymphatic vessel from the PVS. The endothelial cells of lymphatic vessels as well as PCVs are often infiltrated by lymphocytes, particularly more heavily during acute involution of the thymus. These images represent the migration of lymphocytes into the blood or lymphatic microcirculation.
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